BIOPHARMACEUTICS AND CLINICAL PHARMACOKINETICS BY MILO GIBALDI PDF

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DeepDyve Biopharmaceutics and clinical pharmacokinetics. Fourth Edition. By Milo Gibaldi. Lea and Febiger: Malvem, PA, Price not given Biopharmaceutics and clinical pharmacokinetics. Lea and Febiger Slaughter, Richard L. Alka, K. Phurmazie ,44, Linch, F. Winter, C. A,; Risley, E. Nebould, 0. Koster, R. Loux, J.

Tallarda, R. Lea and Febiger: Malvern, PA, ISBN Price not given. This volume, one of the standard textbooks for undergraduate pharmacy students, provides an excellent foundation in principles of biopharmaceutics and pharmacokinetics and covers a wide range of topics in varying degrees of detail.

Emphasis is on explanation of principles with specific examples from the literature. Examples, well-supplemented with figures from primary sources, include basic research, such as a study that evaluated brain distribution of iodoantipyrine in monkeys when administered a t slow and fast infusion rates. Also included are numerous citations from clinical studies. References are both relevant and current through Presentation of equations and mathematics is a t an appropriate level for undergraduate students, but not with the rigor required for graduate students.

A brief introduction to pharmacokinetics and a short chapter providing the basics necessary to evaluate compartmental and noncompartmental pharmacokinetics are included. Only elementary coverage is provided on the principles of pharmaccdynamics.

A noted omission in this chapter is the lack of any discussion concerning situations where a lag time exists between concentration of drug and response. This chapter provides direct relevance to the area of clinical pharmacokinetics and helps to enhance the relevance of this field t o undergraduate students.

However, there are more complete textbooks that cover the pharmacokinetics of individual drugs in much greater detail. This fourth edition is an excellent textbook for undergraduate pharmacy students and is also a useful reference text for basic principles in drug absorption and disposition.

As such, it is a welcome addition to the library of drug information centers and individual pharmacists practicing or researching in the area of clinical pharmacokinetics. Other texts are more appropriate for graduate students and in situations where a reference text is needed that focuses on the applied pharmacokinetics of individual drugs. Richard L.

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