LYOPHILIZER PRINCIPLE PDF

What is a Lyophilizer? How does it work? View Larger Image Lyophilizer , also known as freeze dryer or liofilizador, they are synonymous. Lyophilizer works by freezing the material, then reducing the surround to allow the frozen water ice to sublimate. That means, a lyophilizer will have systems of: refrigeration, vacuum, heating, drying chamber, vapor collect condenser and controller, as well as the auxiliary components like temperature probes, vacuum sensors, software and so on. Sublimation is the process of transition of a substance from solid to the vapor state without passing through an intermediate liquid phase.

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What is a Lyophilizer? How does it work? View Larger Image Lyophilizer , also known as freeze dryer or liofilizador, they are synonymous. Lyophilizer works by freezing the material, then reducing the surround to allow the frozen water ice to sublimate. That means, a lyophilizer will have systems of: refrigeration, vacuum, heating, drying chamber, vapor collect condenser and controller, as well as the auxiliary components like temperature probes, vacuum sensors, software and so on.

Sublimation is the process of transition of a substance from solid to the vapor state without passing through an intermediate liquid phase. The process of lyophilization consists of: Freezing of the product to convert the water in the product to ice form, Sublimation of ice directly into water vapor under vacuum. Drawing off the water vapor Once the ice has been sublimated, the products are freeze-dried and can be removed from machine.

Freezing Phase A lyophilizer uses various methods to freeze the product. Freezing can be done in a freezer, a chilled bath shell freezer , or on a shelf in the lyophilizer.

The lyophilizer cools the material below its triple point to ensure that sublimation, rather than melting, will occur. A lyophilizer most easily freeze dries large ice crystals, which can be produced by slow freezing or annealing. However, with biological materials, when crystals are too large they may break the cell walls, and that leads to less-than-ideal freeze drying results.

To prevent this, the freezing is done rapidly. For materials that tend to precipitate, annealing can be used. This process involves fast freezing, then raising the product temperature to allow the crystals to grow.

The condenser also protects the vacuum pump from the water vapor. Primary drying can be a slow process. Too much heat can alter the structure of the material. By raising the temperature higher than in the primary drying phase, the bonds are broken between the material and the water molecules.

Freeze dried materials retain a porous structure. After the lyophilizer completes its process, the vacuum can be broken with an inert gas before the material is sealed. Eutectic point freezing point , which mentioned above, is the lowest temperature that could completely freezing material to solid. Proper give energy in sublimation step Heating the product too high in temperature can cause many troubles: Product melt.

For example, carbohydrate will block the vapor channel, cause drying fail. Too much vapor creation. Condenser cannot collect in time, and the temperature will have a drastic raise.

Vacuum pump broken. Vapors that cannot collect by condenser in time may go to vacuum pump, oil pump will broken.

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What is a Lyophilizer? How does it work?

Principle and process of lyophilization : Principle and process of lyophilization By, Y. Sunaina M. Triple point :point were 3 phases liquid,solid,vapour coexist at particular temperature and pressure. Latent heat : heat is gained by a substance or system without accompanying rise in temperature during a change of a stage 4 Slide 5: Eutetic point : A eutectic system is a mixture of chemical compounds that has a single chemical composition that solidifies at a lower temperature than any other composition made up of the same ingredients. This composition is known as the eutectic composition and the temperature is known as the eutectic temperature.

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Freeze-drying

Lyophilizer vs. Freeze Dryer What is a lyophilizer? How does it work? A lyophilizer executes a water removal process typically used to preserve perishable materials, to extend shelf life or make the material more convenient for transport. Lyophilizers work by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to sublimate. Freezing Phase A lyophilizer uses various methods to freeze the product.

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Basic Principles of Freeze Drying

Learn how and when to remove this template message Freeze-drying causes less damage to the substance than other dehydration methods using higher temperatures. Nutrient factors that are sensitive to heat are lost less in the process as compared to the processes incorporating heat treatment for drying purposes. In addition, flavours, smells, and nutritional content generally remain unchanged, making the process popular for preserving food. However, water is not the only chemical capable of sublimation , and the loss of other volatile compounds such as acetic acid vinegar and alcohols can yield undesirable results.

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